6 CFR § 46.120 - Evaluation and disposition of applications and proposals for research to be conducted or supported by a Federal department or agency.

---
identifier: "/us/cfr/t6/s46.120"
source: "ecfr"
legal_status: "authoritative_unofficial"
title: "6 CFR § 46.120 - Evaluation and disposition of applications and proposals for research to be conducted or supported by a Federal department or agency."
title_number: 6
title_name: "Domestic Security"
section_number: "46.120"
section_name: "Evaluation and disposition of applications and proposals for research to be conducted or supported by a Federal department or agency."
chapter_name: "DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY"
part_number: "46"
part_name: "PROTECTION OF HUMAN SUBJECTS"
positive_law: false
currency: "2026-03-24"
last_updated: "2026-03-24"
format_version: "1.1.0"
generator: "[email protected]"
authority: "5 U.S.C. 301; Pub. L. 107-296, sec. 102, 306(c); Pub. L. 108-458, sec. 8306."
regulatory_source: "82 FR 7269, Jan. 19, 2017, unless otherwise noted."
cfr_part: "46"
---


# 46.120 Evaluation and disposition of applications and proposals for research to be conducted or supported by a Federal department or agency.

(a) The department or agency head will evaluate all applications and proposals involving human subjects submitted to the Federal department or agency through such officers and employees of the Federal department or agency and such experts and consultants as the department or agency head determines to be appropriate. This evaluation will take into consideration the risks to the subjects, the adequacy of protection against these risks, the potential benefits of the research to the subjects and others, and the importance of the knowledge gained or to be gained.

(b) On the basis of this evaluation, the department or agency head may approve or disapprove the application or proposal, or enter into negotiations to develop an approvable one.