21 CFR § 181.27 - Plasticizers.

---
identifier: "/us/cfr/t21/s181.27"
source: "ecfr"
legal_status: "authoritative_unofficial"
title: "21 CFR § 181.27 - Plasticizers."
title_number: 21
title_name: "Food and Drugs"
section_number: "181.27"
section_name: "Plasticizers."
chapter_name: "FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES"
subchapter_number: "B"
subchapter_name: "FOOD FOR HUMAN CONSUMPTION"
part_number: "181"
part_name: "PRIOR-SANCTIONED FOOD INGREDIENTS"
positive_law: false
currency: "2026-04-05"
last_updated: "2026-04-05"
format_version: "1.1.0"
generator: "[email protected]"
authority: "21 U.S.C. 321, 342, 348, 371."
regulatory_source: "42 FR 14638, Mar. 15, 1977, unless otherwise noted."
cfr_part: "181"
---


# 181.27 Plasticizers.

Substances classified as plasticizers, when migrating from food-packaging material shall include:

Acetyl tributyl citrate.

Acetyl triethyl citrate.

*p-tert-*Butylphenyl salicylate.

Butyl stearate.

Butylphthalyl butyl glycolate.

Dibutyl sebacate.

Di-(2-ethylhexyl) phthalate (for foods of high water content only).

Diethyl phthalate.

Diisobutyl adipate.

Diisooctyl phthalate (for foods of high water content only).

Diphenyl-2-ethylhexyl phosphate.

Epoxidized soybean oil (iodine number maximum 6; and oxirane oxygen, minimum, 6.0 percent).

Ethylphthalyl ethyl glycolate.

Glycerol monooleate.

Monoisopropyl citrate.

Mono, di-, and tristearyl citrate.

Triacetin (glycerol triacetate).

Triethyl citrate.

3-(2-Xenolyl)-1,2-epoxypropane.

[42 FR 14638, Mar. 15, 1977; 42 FR 56728, Oct. 28, 1977, as amended at 50 FR 49536, Dec. 3, 1985]