21 CFR § 290.1 - Controlled substances.

---
identifier: "/us/cfr/t21/s290.1"
source: "ecfr"
legal_status: "authoritative_unofficial"
title: "21 CFR § 290.1 - Controlled substances."
title_number: 21
title_name: "Food and Drugs"
section_number: "290.1"
section_name: "Controlled substances."
chapter_name: "FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES"
subchapter_number: "C"
subchapter_name: "DRUGS: GENERAL"
part_number: "290"
part_name: "CONTROLLED DRUGS"
positive_law: false
currency: "2026-04-05"
last_updated: "2026-04-05"
format_version: "1.1.0"
generator: "[email protected]"
authority: "21 U.S.C. 352, 353, 355, 371."
regulatory_source: "40 FR 14040, Mar. 27, 1975, unless otherwise noted."
cfr_part: "290"
---


# 290.1 Controlled substances.

Any drug that is a controlled substance listed in schedule II, III, IV, or V of the Federal Controlled Substances Act or implementing regulations must be dispensed by prescription only as required by section 503(b)(1) of the Federal Food, Drug, and Cosmetic Act unless specifically exempted in § 290.2.

[67 FR 4906, Feb. 1, 2002]