21 CFR § 500.1410 - N-methyl-2-pyrrolidone.

---
identifier: "/us/cfr/t21/s500.1410"
source: "ecfr"
legal_status: "authoritative_unofficial"
title: "21 CFR § 500.1410 - N-methyl-2-pyrrolidone."
title_number: 21
title_name: "Food and Drugs"
section_number: "500.1410"
section_name: "N-methyl-2-pyrrolidone."
chapter_name: "FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES"
subchapter_number: "E"
subchapter_name: "ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS"
part_number: "500"
part_name: "GENERAL"
positive_law: false
currency: "2026-04-05"
last_updated: "2026-04-05"
format_version: "1.1.0"
generator: "[email protected]"
authority: "21 U.S.C. 321, 331, 342, 343, 348, 351, 352, 353, 360b, 371, 379e."
regulatory_source: "40 FR 13802, Mar. 27, 1975, unless otherwise noted."
cfr_part: "500"
---


# 500.1410 N-methyl-2-pyrrolidone.

(a) *Standard for residues.* No residues of *n*-methyl-2-pyrrolidone may be found in the uncooked edible tissues of cattle and swine as determined by methods in paragraph (b) of this section.

(b) *Incorporation by reference.* The standards required in this section are incorporated by reference into this section with the approval of the Director of the Federal Register under 5 U.S.C. 552(a) and 1 CFR part 51. All approved material is available for inspection at the Food and Drug Administration's Dockets Management Staff (HFA-305), 5630 Fishers Lane, Rm. 1061, Rockville, MD 20852, 240-402-7500, between 9 a.m. and 4 p.m., Monday through Friday. It may be obtained from the sources indicated elsewhere in paragraph (b) of this section and at: *https://www.fda.gov/about-fda/center-veterinary-medicine/cvm-foia-electronic-reading-room.* It is also available for inspection at the National Archives and Records Administration (NARA). For information on the availability of this material at NARA, email *[email protected],* or go to: *www.archives.gov/federal-register/cfr/ibr-locations.html.*

(1) Food and Drug Administration, Center for Veterinary Medicine, 7500 Standish Pl., Rockville, MD 20855, 240-402-7002.

(i) “Method of Analysis: *N*-methyl-2-pyrrolidone,” September 26, 2011; the method of analysis for uncooked edible tissues of cattle.

(ii) [Reserved]

(2) Merck Animal Health, 29160 Intervet Lane, Millsboro, DE 19966, 1-800-211-3573.

(i) “Determinative and Confirmatory Procedures for the Analysis of N-Methyl-2-pyrrolidone (NMP) in Swine Liver Tissue using LC-MS/MS,” July 20, 2017; the method of analysis for uncooked edible tissues of swine.

(ii) [Reserved]

(c) *Related conditions of use.* See §§ 522.814, 522.955, and 522.1660a of this chapter.

[87 FR 10966, Feb. 28, 2022, as amended at 88 FR 55562, Aug. 16, 2023]