21 CFR § 520.2130 - Spinosad.

---
identifier: "/us/cfr/t21/s520.2130"
source: "ecfr"
legal_status: "authoritative_unofficial"
title: "21 CFR § 520.2130 - Spinosad."
title_number: 21
title_name: "Food and Drugs"
section_number: "520.2130"
section_name: "Spinosad."
chapter_name: "FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES"
subchapter_number: "E"
subchapter_name: "ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS"
part_number: "520"
part_name: "ORAL DOSAGE FORM NEW ANIMAL DRUGS"
positive_law: false
currency: "2026-04-05"
last_updated: "2026-04-05"
format_version: "1.1.0"
generator: "[email protected]"
authority: "21 U.S.C. 360b."
regulatory_source: "40 FR 13838, Mar. 27, 1975, unless otherwise noted."
cfr_part: "520"
---


# 520.2130 Spinosad.

(a) *Specifications.* Each chewable tablet contains 140, 270, 560, 810, or 1620 milligrams (mg) spinosad.

(b) *Sponsor.* See No. 058198 in § 510.600 of this chapter.

(c) *Special considerations.* Federal law restricts this drug to use by or on the order of a licensed veterinarian.

(d) *Conditions of use*—(1) *Dogs*—(i) *Amount.* Administer tablets once a month at a recommended minimum dosage of 13.5 mg per pound (30 mg per kilogram) of body weight.

(ii) *Indications for use.* To kill fleas and for the prevention and treatment of flea infestations (*Ctenocephalides felis*) for 1 month on dogs and puppies 14 weeks of age and older and 5.0 pounds of body weight or greater.

(2) *Cats*—(i) *Amount.* Administer tablets once a month at a minimum dosage of 22.5 mg per pound (50 mg per kilogram) of body weight.

(ii) *Indications for use.* To kill fleas and for the prevention and treatment of flea infestations (*C. felis*) for 1 month on cats and kittens 14 weeks of age and older and 4.1 pounds of body weight or greater.

[77 FR 60623, Oct. 4, 2012, as amended at 81 FR 48702, July 26, 2016; 87 FR 10968, Feb. 28, 2022; 89 FR 85426, Oct. 28, 2024]