21 CFR § 520.447 - Clindamycin solution.

---
identifier: "/us/cfr/t21/s520.447"
source: "ecfr"
legal_status: "authoritative_unofficial"
title: "21 CFR § 520.447 - Clindamycin solution."
title_number: 21
title_name: "Food and Drugs"
section_number: "520.447"
section_name: "Clindamycin solution."
chapter_name: "FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES"
subchapter_number: "E"
subchapter_name: "ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS"
part_number: "520"
part_name: "ORAL DOSAGE FORM NEW ANIMAL DRUGS"
positive_law: false
currency: "2026-04-05"
last_updated: "2026-04-05"
format_version: "1.1.0"
generator: "[email protected]"
authority: "21 U.S.C. 360b."
regulatory_source: "40 FR 13838, Mar. 27, 1975, unless otherwise noted."
cfr_part: "520"
---


# 520.447 Clindamycin solution.

(a) *Specifications.* Each milliliter of solution contains the equivalent of 25 milligrams (mg) clindamycin as the hydrochloride salt.

(b) *Sponsors.* See Nos. 051311, 054771, 058829, 061133, and 069043 in § 510.600(c) of this chapter.

(c) *Special considerations.* Federal law restricts this drug to use by or on the order of a licensed veterinarian.

(d) *Conditions of use*—(1) *Dogs*—(i) *Amount.* Wounds, abscesses, and dental infections: 2.5 to 15 mg per pound (/lb) body weight every 12 hours for a maximum of 28 days. Osteomyelitis: 5.0 to 15 mg/lb body weight every 12 hours for a minimum of 28 days.

(ii) *Indications for use.* For the treatment of skin infections (wounds and abscesses) due to susceptible strains of coagulase-positive staphylococci (*Staphylococcus aureus* or *S. intermedius*), deep wounds and abscesses due to susceptible strains of *Bacteroides fragilis*, *Prevotella melaninogenicus*, *Fusobacterium necrophorum*, and *Clostridium perfringens*; dental infections due to susceptible strains of *S. aureus*, *B. fragilis*, *P. melaninogenicus*, *F. necrophorum*, and *C. perfringens*; and osteomyelitis due to susceptible strains of *S. aureus*, *B. fragilis*, *P. melaninogenicus*, *F. necrophorum*, and *C. perfringens.*

(2) Cats—(i) *Amount.* 5.0 to 15.0 mg/lb body weight every 24 hours for a maximum of 14 days.

(ii) *Indications for use.* For the treatment of skin infections (wounds and abscesses) due to susceptible strains of *Staphylococcus aureus*, *S. intermedius*, *Streptococcus spp.*; deep wounds and abscesses due to susceptible strains of *Clostridium perfringens* and *Bacteroides fragilis*; and dental infections due to susceptible strains of *S. aureus*, *S. intermedius*, *Streptococcus spp.*, *C. perfringens*, and *B. fragilis.*

[67 FR 54954, Aug. 27, 2002, as amended at 67 FR 78684, Dec. 26, 2002; 68 FR 55824, Sept. 29, 2003; 69 FR 31734, June 7, 2004; 71 FR 39543, July 13, 2006; 72 FR 19796, Apr. 20, 2007; 78 FR 17596, Mar. 22, 2013; 78 FR 30197, May 22, 2013; 79 FR 28819, May 20, 2014; 81 FR 17607, Mar. 30, 2016; 84 FR 8972, Mar. 13, 2019]