21 CFR § 520.88e - Amoxicillin trihydrate boluses.

---
identifier: "/us/cfr/t21/s520.88e"
source: "ecfr"
legal_status: "authoritative_unofficial"
title: "21 CFR § 520.88e - Amoxicillin trihydrate boluses."
title_number: 21
title_name: "Food and Drugs"
section_number: "520.88e"
section_name: "Amoxicillin trihydrate boluses."
chapter_name: "FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES"
subchapter_number: "E"
subchapter_name: "ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS"
part_number: "520"
part_name: "ORAL DOSAGE FORM NEW ANIMAL DRUGS"
positive_law: false
currency: "2026-04-05"
last_updated: "2026-04-05"
format_version: "1.1.0"
generator: "[email protected]"
authority: "21 U.S.C. 360b."
regulatory_source: "40 FR 13838, Mar. 27, 1975, unless otherwise noted."
cfr_part: "520"
---


# 520.88e Amoxicillin trihydrate boluses.

(a) *Specifications.* Each bolus contains amoxicillin trihydrate equivalent to 400 milligrams (mg) amoxicillin.

(b) *Sponsor.* See No. 054771 in § 510.600(c) of this chapter.

(c) *Related tolerances.* See § 556.38 of this chapter.

(d) *Conditions of use in cattle*—(1) *Amount.* Administer 400 mg per 100 pounds of body weight twice daily. Treatment should be continued for 48 hours after all symptoms have subsided but not to exceed 5 days.

(2) *Indications for use.* Treatment of bacterial enteritis when due to susceptible *Escherichia coli* in preruminating calves including veal calves.

(3) *Limitations.* Do not slaughter animals during treatment or for 20 days after the latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

[57 FR 37320, Aug. 18, 1992, as amended at 60 FR 55659, Nov. 2, 1995; 62 FR 5526, Feb. 6, 1997; 79 FR 28817, May 20, 2014]