21 CFR § 522.2670 - Yohimbine.
---
identifier: "/us/cfr/t21/s522.2670"
source: "ecfr"
legal_status: "authoritative_unofficial"
title: "21 CFR § 522.2670 - Yohimbine."
title_number: 21
title_name: "Food and Drugs"
section_number: "522.2670"
section_name: "Yohimbine."
chapter_name: "FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES"
subchapter_number: "E"
subchapter_name: "ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS"
part_number: "522"
part_name: "IMPLANTATION OR INJECTABLE DOSAGE FORM NEW ANIMAL DRUGS"
positive_law: false
currency: "2026-04-05"
last_updated: "2026-04-05"
format_version: "1.1.0"
generator: "[email protected]"
authority: "21 U.S.C. 360b."
regulatory_source: "40 FR 13858, Mar. 27, 1975, unless otherwise noted."
cfr_part: "522"
---
# 522.2670 Yohimbine.
(a) *Specifications.* Each milliliter (mL) of solution contains 2 or 5 milligrams (mg) of yohimbine (as hydrochloride).
(b) *Sponsors.* See sponsors in § 510.600(c) of this chapter for use as in paragraph (c) of this section.
(1) No. 059399 for use of in 2 mg/mL solution as in paragraph (c)(1) of this section.
(2) No. 053923 for use of in 5 mg/mL solution as in paragraph (c)(2) of this section.
(c) *Conditions of use*—(1) *Dogs*—(i) *Amount.* Administer 0.05 mg per pound (0.11 mg per kilogram) of body weight by intravenous injection.
(ii) *Indications for use.* To reverse the effects of xylazine in dogs.
(iii) *Limitations.* Not for use in food-producing animals. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
(2) *Deer and elk*—(i) *Amount.* Administer 0.2 to 0.3 mg per kilogram of body weight by intravenous injection.
(ii) *Indications for use.* A s an antagonist to xylazine sedation in free ranging or confined members of the family Cervidae (deer and elk).
(iii) *Limitations.* Do not use in domestic food-producing animals. Do not use for 30 days before or during hunting season. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
[79 FR 74020, Dec. 15, 2014, as amended at 80 FR 13230, Mar. 13, 2015]