21 CFR § 522.380 - Chloral hydrate, pentobarbital, and magnesium sulfate.

---
identifier: "/us/cfr/t21/s522.380"
source: "ecfr"
legal_status: "authoritative_unofficial"
title: "21 CFR § 522.380 - Chloral hydrate, pentobarbital, and magnesium sulfate."
title_number: 21
title_name: "Food and Drugs"
section_number: "522.380"
section_name: "Chloral hydrate, pentobarbital, and magnesium sulfate."
chapter_name: "FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES"
subchapter_number: "E"
subchapter_name: "ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS"
part_number: "522"
part_name: "IMPLANTATION OR INJECTABLE DOSAGE FORM NEW ANIMAL DRUGS"
positive_law: false
currency: "2026-04-05"
last_updated: "2026-04-05"
format_version: "1.1.0"
generator: "[email protected]"
authority: "21 U.S.C. 360b."
regulatory_source: "40 FR 13858, Mar. 27, 1975, unless otherwise noted."
cfr_part: "522"
---


# 522.380 Chloral hydrate, pentobarbital, and magnesium sulfate.

(a) *Specifications.* Each milliliter of solution contains 42.5 milligrams (mg) of chloral hydrate, 8.86 mg of pentobarbital, and 21.2 mg of magnesium sulfate.

(b) *Sponsor.* See No. 054771 in § 510.600(c) of this chapter.

(c) *Conditions of use*—(1) *Amount.* For general anesthesia: Administer 20 to 50 milliliters per 100 pounds of body weight by intravenous injection until the desired effect is produced. Cattle usually require a lower dosage on the basis of body weight. As a sedative-relaxant: Administer at a level of one-fourth to one-half of the anesthetic dosage level.

(2) *Indications for use.* For general anesthesia and as a sedative-relaxant in cattle and horses.

(3) *Limitations.* Federal law restricts this drug to use by or on the order of a licensed veterinarian.

[79 FR 16185, Mar. 25, 2014]