21 CFR § 529.400 - Chlorhexidine tablets and suspension.

---
identifier: "/us/cfr/t21/s529.400"
source: "ecfr"
legal_status: "authoritative_unofficial"
title: "21 CFR § 529.400 - Chlorhexidine tablets and suspension."
title_number: 21
title_name: "Food and Drugs"
section_number: "529.400"
section_name: "Chlorhexidine tablets and suspension."
chapter_name: "FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES"
subchapter_number: "E"
subchapter_name: "ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS"
part_number: "529"
part_name: "CERTAIN OTHER DOSAGE FORM NEW ANIMAL DRUGS"
positive_law: false
currency: "2026-04-05"
last_updated: "2026-04-05"
format_version: "1.1.0"
generator: "[email protected]"
authority: "21 U.S.C. 360b."
regulatory_source: "40 FR 13881, Mar. 27, 1975, unless otherwise noted."
cfr_part: "529"
---


# 529.400 Chlorhexidine tablets and suspension.

(a) *Specification.* Each tablet and each 28-milliliter syringe of suspension contain 1 gram of chlorhexidine dihydrochloride.

(b) *Sponsor.* See No. 054771 in § 510.600(c) of this chapter.

(c) *Related tolerances.* See § 556.120 of this chapter.

(d) *Conditions of use*—(1) *Amount.* Place 1 or 2 tablets deep in each uterine horn; or infuse a solution of 1 tablet disolved in an appropriate amount of clean boiled water; or infuse one syringe of suspension into the uterus.

(2) *Indications for use.* For prevention or treatment of metritis and vaginitis in cows and mares when caused by pathogens sensitive to chlorhexidine dihydrochloride.

(3) *Limitations.* Prior to administration, remove any unattached placental membranes, any excess uterine fluid or debris, and carefully clean external genitalia. Use a clean, sterile inseminating pipette for administrating solutions and suspensions. Treatment may be repeated in 48 to 72 hours.

[43 FR 10705, Feb. 23, 1979, as amended at 79 FR 10973, Feb. 27, 2014; 81 FR 67152, Sept. 30, 2016; 84 FR 32993, July 11, 2019]