21 CFR § 529.778 - Doxycycline.

---
identifier: "/us/cfr/t21/s529.778"
source: "ecfr"
legal_status: "authoritative_unofficial"
title: "21 CFR § 529.778 - Doxycycline."
title_number: 21
title_name: "Food and Drugs"
section_number: "529.778"
section_name: "Doxycycline."
chapter_name: "FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES"
subchapter_number: "E"
subchapter_name: "ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS"
part_number: "529"
part_name: "CERTAIN OTHER DOSAGE FORM NEW ANIMAL DRUGS"
positive_law: false
currency: "2026-04-05"
last_updated: "2026-04-05"
format_version: "1.1.0"
generator: "[email protected]"
authority: "21 U.S.C. 360b."
regulatory_source: "40 FR 13881, Mar. 27, 1975, unless otherwise noted."
cfr_part: "529"
---


# 529.778 Doxycycline.

(a) *Specifications.* Doxycycline hyclate solution contains 8.5 percent doxycycline activity. A syringe of N-methyl-2-pyrrolidone and poly (DL-lactide) mixed with a syringe of doxycycline produces 0.5 milliliter of solution.

(b) *Sponsor.* See 054771 in § 510.600(c) of this chapter.

(c) *Conditions of use in dogs*—(1) *Amount.* Apply subgingivally to periodontal pocket(s) of affected teeth.

(2) *Indications for use.* For treatment and control of periodontal disease.

(3) *Limitations.* Federal law restricts this drug to use by or on the order of a licensed veterinarian.

[79 FR 10973, Feb. 27, 2014]