21 CFR § 556.113 - Ceftiofur.

---
identifier: "/us/cfr/t21/s556.113"
source: "ecfr"
legal_status: "authoritative_unofficial"
title: "21 CFR § 556.113 - Ceftiofur."
title_number: 21
title_name: "Food and Drugs"
section_number: "556.113"
section_name: "Ceftiofur."
chapter_name: "FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES"
subchapter_number: "E"
subchapter_name: "ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS"
part_number: "556"
part_name: "TOLERANCES FOR RESIDUES OF NEW ANIMAL DRUGS IN FOOD"
positive_law: false
currency: "2026-04-05"
last_updated: "2026-04-05"
format_version: "1.1.0"
generator: "[email protected]"
authority: "21 U.S.C. 342, 360b, 371."
regulatory_source: "84 FR 32993, July 11, 2019, unless otherwise noted."
cfr_part: "556"
---


# 556.113 Ceftiofur.

(a) *Acceptable daily intake and acute reference dose*—(1) *Acceptable daily intake (ADI).* The ADI for total residue of ceftiofur is 30 µg/kg of body weight per day.

(2) *Acute reference dose (ARfD).* The ARfD for total residue of ceftiofur is 0.830 mg/kg of body weight.

(b) *Tolerances.* The tolerances for desfuroylceftiofur (marker residue) are:

(1) *Cattle.* (i) Kidney (target tissue): 0.4 ppm.

(ii) Liver: 2 ppm.

(iii) Muscle: 1 ppm.

(iv) Milk: 0.1 ppm.

(2) *Chickens and turkeys.* Edible tissues (excluding eggs): Not required.

(3) *Goats.* (i) Kidney (target tissue): 8 ppm.

(ii) Liver: 2 ppm.

(iii) Muscle: 1 ppm.

(iv) Milk: 0.1 ppm.

(4) *Sheep.* Edible tissues (excluding milk): Not required.

(5) *Swine.* (i) Kidney (target tissue): 0.25 ppm.

(ii) Liver: 3 ppm.

(iii) Muscle: 2 ppm.

(c) *Related conditions of use.* See §§ 522.313a, 522.313b, 522.313c, and 526.313 of this chapter.