21 CFR § 556.500 - Oxytetracycline.

---
identifier: "/us/cfr/t21/s556.500"
source: "ecfr"
legal_status: "authoritative_unofficial"
title: "21 CFR § 556.500 - Oxytetracycline."
title_number: 21
title_name: "Food and Drugs"
section_number: "556.500"
section_name: "Oxytetracycline."
chapter_name: "FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES"
subchapter_number: "E"
subchapter_name: "ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS"
part_number: "556"
part_name: "TOLERANCES FOR RESIDUES OF NEW ANIMAL DRUGS IN FOOD"
positive_law: false
currency: "2026-04-05"
last_updated: "2026-04-05"
format_version: "1.1.0"
generator: "[email protected]"
authority: "21 U.S.C. 342, 360b, 371."
regulatory_source: "84 FR 32993, July 11, 2019, unless otherwise noted."
cfr_part: "556"
---


# 556.500 Oxytetracycline.

(a) *Acceptable daily intake (ADI).* The ADI for total tetracycline residues (chlortetracycline, oxytetracycline, and tetracycline) is 25 µg/kg of body weight per day.

(b) *Tolerances.* The tolerances for the sum of tetracycline residues are:

(1) *Cattle.* (i) Muscle: 2 ppm.

(ii) Liver: 6 ppm.

(iii) Fat and kidney: 12 ppm.

(iv) Milk: 0.3 ppm.

(2) *Chickens and turkeys.* (i) Muscle: 2 ppm.

(ii) Liver: 6 ppm.

(iii) Fat and kidney: 12 ppm.

(3) *Finfish.* Muscle (with adhering skin when edible): 2 ppm.

(4) *Lobster.* Muscle: 2 ppm.

(5) *Swine and sheep.* (i) Muscle: 2 ppm.

(ii) Liver: 6 ppm.

(iii) Fat and kidney: 12 ppm.

(6) *Honey.* 750 ppb.

(c) *Related conditions of use.* See §§ 520.1660c, 520.1660d, 520.1664, 522.1660a, 522.1660b, 522.1662, 522.1664, 529.1660, 558.450, and 558.455 of this chapter.

[84 FR 32993, July 11, 2019, as amended at 85 FR 18121, Apr. 1, 2020; 88 FR 16549, Mar. 20, 2023, 88 FR 55567, Aug. 16, 2023]