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21 CFR § 558.185 - Coumaphos.

---
identifier: "/us/cfr/t21/s558.185"
source: "ecfr"
legal_status: "authoritative_unofficial"
title: "21 CFR § 558.185 - Coumaphos."
title_number: 21
title_name: "Food and Drugs"
section_number: "558.185"
section_name: "Coumaphos."
chapter_name: "FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES"
subchapter_number: "E"
subchapter_name: "ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS"
part_number: "558"
part_name: "NEW ANIMAL DRUGS FOR USE IN ANIMAL FEEDS"
positive_law: false
currency: "2026-04-05"
last_updated: "2026-04-05"
format_version: "1.1.0"
generator: "[email protected]"
authority: "21 U.S.C. 354, 360b, 360ccc, 360ccc-1, 371."
regulatory_source: "40 FR 13959, Mar. 27, 1975, unless otherwise noted."
cfr_part: "558"
---

# 558.185 Coumaphos.

(a) *Specifications.* Type A medicated articles containing 1.12, 2.0, 11.2, or 50 percent coumaphos.

(b) *Sponsor.* See No. 058198 in § 510.600(c) of this chapter.

(c) *Related tolerances.* See § 556.168 of this chapter.

(d) *Special considerations.* (1) Labeling shall bear the following warning: The active ingredient coumaphos is a cholinesterase inhibitor. Do not use this product on animals simultaneously or within a few days before or after treatment with, or exposure to, cholinesterase-inhibiting drugs, pesticides, or chemicals.

(2) See § 500.25 of this chapter.

(e) *Conditions of use in laying chickens.*

| Coumaphos ingrams per ton | Indications for use | Limitations | Sponsor |
| --- | --- | --- | --- |
| (1) 27.2 (0.003 percent) | Laying chickens: For control of capillary worm () and as an aid in control of common round worm () and cecal worm () | Feed continuously as the sole ration for 14 days. If reinfection occurs, treatment may be repeated, but not sooner than 3 weeks after the end of the previous treatment. Do not feed to chickens within 10 days of vaccination or other conditions of stress. | 058198 |
| (2) 36.3 (0.004 percent) | Replacement pullets: For control of capillary worm () and as an aid in control of common round worm () and cecal worm () | Feed continuously as the sole ration for from 10 to 14 days. Do not feed to chickens under 8 weeks of age or within 10 days of vaccination or other conditions of stress. If birds are maintained on contaminated litter or exposed to infected birds, a second 10- to 14-day treatment is recommended, but not sooner than 3 weeks after the end of the previous treatment. If reinfection occurs after production begins, repeat treatment as recommended for laying flocks. | 058198 |

[86 FR 14822, Mar. 19, 2021]