21 CFR § 558.248 - Erythromycin.

---
identifier: "/us/cfr/t21/s558.248"
source: "ecfr"
legal_status: "authoritative_unofficial"
title: "21 CFR § 558.248 - Erythromycin."
title_number: 21
title_name: "Food and Drugs"
section_number: "558.248"
section_name: "Erythromycin."
chapter_name: "FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES"
subchapter_number: "E"
subchapter_name: "ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS"
part_number: "558"
part_name: "NEW ANIMAL DRUGS FOR USE IN ANIMAL FEEDS"
positive_law: false
currency: "2026-04-05"
last_updated: "2026-04-05"
format_version: "1.1.0"
generator: "[email protected]"
authority: "21 U.S.C. 354, 360b, 360ccc, 360ccc-1, 371."
regulatory_source: "40 FR 13959, Mar. 27, 1975, unless otherwise noted."
cfr_part: "558"
---


# 558.248 Erythromycin.

(a) *Specifications.* Type A medicated articles containing 92.5 grams per pound erythromycin (as the thiocyanate salt).

(b) *Sponsor.* See No. 061133 in § 510.600(c) of this chapter.

(c) *Related tolerances.* See § 556.230 of this chapter.

(d) *Special considerations.* (1) Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian. See § 558.6 for additional requirements.

(2) The expiration date of VFDs for erythromycin medicated feeds must not exceed 6 months from the date of issuance. VFDs for erythromycin shall not be refilled.

(e) *Conditions of use*—(1) *Chickens*—

| Erythromycin in grams/ton | Combination in grams/ton | Indications for use | Limitations | Sponsor |
| --- | --- | --- | --- | --- |
| (i) 92.5 |  | Chickens: As an aid in the prevention of chronic respiratory disease during periods of stress | Feed for 2 days before stress and 3 to 6 days after stress. Withdraw 24 hours before slaughter | 061623 |
| (ii) 92.5 |  | Chickens: As an aid in the prevention of infectious coryza | Feed for 7 to 14 days. Withdraw 24 hours before slaughter | 061623 |
| (iii) 185 |  | Chickens: As an aid in the prevention and reduction of lesions and in lowering severity of chronic respiratory disease (CRD) | Feed for 5 to 8 days. Withdraw 48 hours before slaughter. Do not use in birds producing eggs for food | 061623 |

(2) *Turkeys*—

| Erythromycin thiocyanate in grams/ton | Combination in grams/ton | Indications for use | Limitations | Sponsor |
| --- | --- | --- | --- | --- |
| (i) 92.5 |  | Turkeys: As an aid in the prevention of chronic respiratory disease during periods of stress | Feed for 2 days before stress and 3 to 6 days after stress | 061623 |
| (ii) 185 |  | Turkeys: As an aid in the prevention and reduction of lesions and in lowering severity of chronic respiratory disease (CRD) | Feed for 5 to 8 days. Do not use in birds producing eggs for food | 061623 |

[41 FR 10999, Mar. 15, 1976, as amended at 45 FR 56799, Aug. 26, 1980; 49 FR 31281, Aug. 6, 1984; 51 FR 7397, Mar. 3, 1986; 52 FR 2684, Jan. 26, 1987; 54 FR 12189, Mar. 24, 1989; 66 FR 14074, Mar. 9, 2001; 68 FR 4915, Jan. 31, 2003; 79 FR 10982, Feb. 27, 2014; 81 FR 36790, June 8, 2016; 81 FR 95004, Dec. 27, 2016; 84 FR 8975, Mar. 13, 2019]