21 CFR § 558.59 - Apramycin.

---
identifier: "/us/cfr/t21/s558.59"
source: "ecfr"
legal_status: "authoritative_unofficial"
title: "21 CFR § 558.59 - Apramycin."
title_number: 21
title_name: "Food and Drugs"
section_number: "558.59"
section_name: "Apramycin."
chapter_name: "FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES"
subchapter_number: "E"
subchapter_name: "ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS"
part_number: "558"
part_name: "NEW ANIMAL DRUGS FOR USE IN ANIMAL FEEDS"
positive_law: false
currency: "2026-04-05"
last_updated: "2026-04-05"
format_version: "1.1.0"
generator: "[email protected]"
authority: "21 U.S.C. 354, 360b, 360ccc, 360ccc-1, 371."
regulatory_source: "40 FR 13959, Mar. 27, 1975, unless otherwise noted."
cfr_part: "558"
---


# 558.59 Apramycin.

(a) *Specifications.* Type A articles containing 75 grams apramycin (as apramycin sulfate) per pound.

(b) *Sponsor.* See No. 058198 in § 510.600(c) of this chapter.

(c) *Related tolerances.* See § 556.52 of this chapter.

(d) *Special considerations.* (1) Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian. See § 558.6 for additional requirements.

(2) The expiration date of VFDs for apramycin medicated feeds must not exceed 6 months from the date of issuance. VFDs for apramycin shall not be refilled.

(e) *Conditions of use in swine*—

| Apramycingrams/ton | Combination ingrams/ton | Indications for use | Limitations | Sponsor |
| --- | --- | --- | --- | --- |
| (1) 150 |  | For control of porcine colibacillosis (weanling pig scours) caused by susceptible strains of | Feed as the sole ration for 14 consecutive days. Withdraw 28 days before slaughter | 058198 |
| (2) [Reserved] |  |  |  |  |

[81 FR 94995, Dec. 27, 2016, as amended at 87 FR 10970, Feb. 28, 2022]