21 CFR § 1311.135 - Requirements for creating a controlled substance prescription.

---
identifier: "/us/cfr/t21/s1311.135"
source: "ecfr"
legal_status: "authoritative_unofficial"
title: "21 CFR § 1311.135 - Requirements for creating a controlled substance prescription."
title_number: 21
title_name: "Food and Drugs"
section_number: "1311.135"
section_name: "Requirements for creating a controlled substance prescription."
chapter_name: "DRUG ENFORCEMENT ADMINISTRATION, DEPARTMENT OF JUSTICE"
part_number: "1311"
part_name: "REQUIREMENTS FOR ELECTRONIC ORDERS AND PRESCRIPTIONS"
positive_law: false
currency: "2026-04-05"
last_updated: "2026-04-05"
format_version: "1.1.0"
generator: "[email protected]"
authority: "21 U.S.C. 821, 828, 829, 871(b), 958(e), 965, unless otherwise noted."
regulatory_source: "70 FR 16915, Apr. 1, 2005, unless otherwise noted."
cfr_part: "1311"
---


# 1311.135 Requirements for creating a controlled substance prescription.

(a) The electronic prescription application may allow the registrant or his agent to enter data for a controlled substance prescription, provided that only the registrant may sign the prescription in accordance with §§ 1311.120(b)(11) and 1311.140.

(b) If a practitioner holds multiple DEA registrations, the practitioner or his agent must select the appropriate registration number for the prescription being issued in accordance with the requirements of § 1301.12 of this chapter.

(c) If required by State law, a supervisor's name and DEA number may be listed on a prescription, provided the prescription clearly indicates who is the supervisor and who is the prescribing practitioner.