42 CFR § 81.20 - Required Use of Niosh-irep.

---
identifier: "/us/cfr/t42/s81.20"
source: "ecfr"
legal_status: "authoritative_unofficial"
title: "42 CFR § 81.20 - Required use of NIOSH-IREP."
title_number: 42
title_name: "Public Health"
section_number: "81.20"
section_name: "Required use of NIOSH-IREP."
chapter_name: "PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES"
subchapter_number: "G"
subchapter_name: "OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES"
part_number: "81"
part_name: "GUIDELINES FOR DETERMINING PROBABILITY OF CAUSATION UNDER THE ENERGY EMPLOYEES OCCUPATIONAL ILLNESS COMPENSATION PROGRAM ACT OF 2000"
positive_law: false
currency: "2026-03-24"
last_updated: "2026-03-24"
format_version: "1.1.0"
generator: "[email protected]"
authority: "42 U.S.C. 7384n(c); E.O. 13179, 65 FR 77487, 3 CFR, 2000 Comp., p. 321."
regulatory_source: "67 FR 22309, May 2, 2002, unless otherwise noted."
cfr_part: "81"
---


# 81.20 Required use of NIOSH-IREP.

(a) NIOSH-IREP is an interactive software program for estimating probability of causation for covered employees seeking compensation for cancer under EEOICPA, other than as members of the Special Exposure Cohort seeking compensation for a specified cancer.

(b) DOL is required to use NIOSH-IREP to estimate probability of causation for all cancers, as identified under §§ 81.21 and 81.23.