42 CFR § 81.22 - General guidelines for use of NIOSH-IREP.

---
identifier: "/us/cfr/t42/s81.22"
source: "ecfr"
legal_status: "authoritative_unofficial"
title: "42 CFR § 81.22 - General guidelines for use of NIOSH-IREP."
title_number: 42
title_name: "Public Health"
section_number: "81.22"
section_name: "General guidelines for use of NIOSH-IREP."
chapter_name: "PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES"
subchapter_number: "G"
subchapter_name: "OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES"
part_number: "81"
part_name: "GUIDELINES FOR DETERMINING PROBABILITY OF CAUSATION UNDER THE ENERGY EMPLOYEES OCCUPATIONAL ILLNESS COMPENSATION PROGRAM ACT OF 2000"
positive_law: false
currency: "2026-04-05"
last_updated: "2026-04-05"
format_version: "1.1.0"
generator: "[email protected]"
authority: "42 U.S.C. 7384n(c); E.O. 13179, 65 FR 77487, 3 CFR, 2000 Comp., p. 321."
regulatory_source: "67 FR 22309, May 2, 2002, unless otherwise noted."
cfr_part: "81"
---


# 81.22 General guidelines for use of NIOSH-IREP.

DOL will use procedures specified in the NIOSH-IREP Operating Guide to calculate probability of causation estimates under EEOICPA. The guide provides current, step-by-step instructions for the operation of IREP. The procedures include entering personal, diagnostic, and exposure data; setting/confirming appropriate values for variables used in calculations; conducting the calculation; and, obtaining, evaluating, and reporting results.