42 CFR § 82.19 - How will NIOSH address uncertainty about dose levels?

---
identifier: "/us/cfr/t42/s82.19"
source: "ecfr"
legal_status: "authoritative_unofficial"
title: "42 CFR § 82.19 - How will NIOSH address uncertainty about dose levels?"
title_number: 42
title_name: "Public Health"
section_number: "82.19"
section_name: "How will NIOSH address uncertainty about dose levels?"
chapter_name: "PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES"
subchapter_number: "G"
subchapter_name: "OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES"
part_number: "82"
part_name: "METHODS FOR CONDUCTING DOSE RECONSTRUCTION UNDER THE ENERGY EMPLOYEES OCCUPATIONAL ILLNESS COMPENSATION PROGRAM ACT OF 2000"
positive_law: false
currency: "2026-04-05"
last_updated: "2026-04-05"
format_version: "1.1.0"
generator: "[email protected]"
authority: "42 U.S.C. 7384n(d) and (e); E.O. 13179, 65 FR 77487, 3 CFR, 2000 Comp., p. 321."
regulatory_source: "67 FR 22330, May 2, 2002, unless otherwise noted."
cfr_part: "82"
---


# 82.19 How will NIOSH address uncertainty about dose levels?

The estimate of each annual dose will be characterized with a probability distribution that accounts for the uncertainty of the estimate. This information will be used by DOL in the calculation of probability of causation, under HHS guidelines for calculating probability of causation estimates at 42 CFR 81. In this way, claimants will receive the benefit of the doubt in cases in which the actual dose may have exceeded the best estimate calculated by NIOSH.