21 CFR § 570.245 - Part 5 of a GRAS notice: Experience based on common use in food before 1958.

---
identifier: "/us/cfr/t21/s570.245"
source: "ecfr"
legal_status: "authoritative_unofficial"
title: "21 CFR § 570.245 - Part 5 of a GRAS notice: Experience based on common use in food before 1958."
title_number: 21
title_name: "Food and Drugs"
section_number: "570.245"
section_name: "Part 5 of a GRAS notice: Experience based on common use in food before 1958."
chapter_name: "FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES"
subchapter_number: "E"
subchapter_name: "ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS"
part_number: "570"
part_name: "FOOD ADDITIVES"
positive_law: false
currency: "2026-04-05"
last_updated: "2026-04-05"
format_version: "1.1.0"
generator: "[email protected]"
authority: "21 U.S.C. 321, 341, 342, 346a, 348, 371."
regulatory_source: "41 FR 38644, Sept. 10, 1976, unless otherwise noted."
cfr_part: "570"
---


# 570.245 Part 5 of a GRAS notice: Experience based on common use in food before 1958.

If the statutory basis for your conclusion of GRAS status is through experience based on common use in animal food, in Part 5 of your GRAS notice you must include evidence of a substantial history of consumption of the notified substance for food use by a significant number of animals of the species to which the substance is intended to be fed prior to January 1, 1958, and evidence of a substantial history of consumption by humans consuming human foods derived from food-producing animals prior to January 1, 1958.