Title 21, Part 570 — Food Additives

Definitions.

Opinion letters on food additive status.

Indirect food additives resulting from packaging materials prior sanctioned for animal feed and pet food.

Indirect food additives resulting from packaging materials for animal feed and pet food.

Adoption of regulation on initiative of Commissioner.

Exemption for investigational use and procedure for obtaining authorization to market edible products from experimental animals.

Tolerances for related food additives.

Pesticide chemicals in processed foods.

General principles for evaluating the safety of food additives.

Eligibility for classification as generally recognized as safe (GRAS).

Affirmation of generally recognized as safe (GRAS) status.

Determination of food additive status.

Definitions.

Opportunity to submit a GRAS notice.

How to send your GRAS notice to FDA.

Incorporation into a GRAS notice.

General requirements applicable to a GRAS notice.

Part 1 of a GRAS notice: Signed statements and certification.

Part 2 of a GRAS notice: Identity, method of manufacture, specifications, and physical or technical effect.

Part 3 of a GRAS notice: Target animal and human exposures.

Part 4 of a GRAS notice: Self-limiting levels of use.

Part 5 of a GRAS notice: Experience based on common use in food before 1958.

Part 6 of a GRAS notice: Narrative.

Part 7 of a GRAS notice: List of supporting data and information in your GRAS notice.

Steps you may take before FDA responds to your GRAS notice.

What FDA will do with a GRAS notice.

Public disclosure of a GRAS notice.

Submission of a supplement.