21 CFR § 570.280 - Submission of a supplement.

---
identifier: "/us/cfr/t21/s570.280"
source: "ecfr"
legal_status: "authoritative_unofficial"
title: "21 CFR § 570.280 - Submission of a supplement."
title_number: 21
title_name: "Food and Drugs"
section_number: "570.280"
section_name: "Submission of a supplement."
chapter_name: "FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES"
subchapter_number: "E"
subchapter_name: "ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS"
part_number: "570"
part_name: "FOOD ADDITIVES"
positive_law: false
currency: "2026-04-05"
last_updated: "2026-04-05"
format_version: "1.1.0"
generator: "[email protected]"
authority: "21 U.S.C. 321, 341, 342, 346a, 348, 371."
regulatory_source: "41 FR 38644, Sept. 10, 1976, unless otherwise noted."
cfr_part: "570"
---


# 570.280 Submission of a supplement.

If circumstances warrant, you may submit a supplement to a filed GRAS notice after we respond to your notice by letter in accordance with § 570.265(b)(1) or cease to evaluate your notice in accordance with § 570.265(b)(3).